Dr. Metin Sitti is the director of the Physical Intelligence Department at the Max Planck Institute for Intelligent Systems in Stuttgart, Germany. He is also an honorary professor in University of Stuttgart, professor in Koç University, Istanbul, Turkey, and distinguished service professor in Carnegie Mellon University. He was a professor in the Department of Mechanical Engineering and in the Robotics Institute at Carnegie Mellon University, USA (2002-2014) and a research scientist at University of California at Berkeley, USA (1999-2002). He received the BSc (1992) and MSc (1994) degrees in electrical and electronics engineering from Boğaziçi University, Turkey, and the PhD degree (1999) in electrical engineering from the University of Tokyo, Japan.
He is an IEEE Fellow. As selected awards, he received the ERC Advanced Grant (2019), Rahmi Koç Medal of Science (2018), Best Paper Award in the Robotics Science and Systems Conference (2019), IEEE/ASME Best Mechatronics Paper Award (2014), SPIE Nanoengineering Pioneer Award (2011), Best Paper Award in the IEEE/RSJ Intelligent Robots and Systems Conference (1998, 2009), and NSF CAREER Award (2005). He has published over 440 peer-reviewed papers, over 240 of which have appeared in archival journals. He is the editor-in-chief of both Progress in Biomedical Engineering and Journal of Micro-Bio Robotics. His research interests include physical intelligence, small-scale mobile robotics, bio-inspiration, advanced functional micro/nanomaterials, and miniature medical devices.
Proceedings of the IEEE, 103(2):205-224, IEEE, March 2015 (article)
Untethered robots miniaturized to the length scale of millimeter and below attract growing attention for the prospect of transforming many aspects of health care and bioengineering. As the robot size goes down to the order of a single cell, previously inaccessible body sites would become available for high-resolution in situ and in vivo manipulations. This unprecedented direct access would enable an extensive range of minimally invasive medical operations. Here, we provide a comprehensive review of the current advances in biomedical untethered mobile milli/microrobots. We put a special emphasis on the potential impacts of biomedical microrobots in the near future. Finally, we discuss the existing challenges and emerging concepts associated with designing such a miniaturized robot for operation inside a biological environment for biomedical applications.
Song, J., Shawky, J., Kim, Y. T., Hazar, M., Sitti, M., LeDuc, P. R., Davidson, L. A.
Biophysical Journal, 108(2):455a, Elsevier, January 2015 (article)
Cells in tissues encounter a range of physical cues as they migrate. Probing single cell and collective migratory responses to physically defined three-dimensional (3D) microenvironments and the factors that modulate those responses are critical to understanding how tissue migration is regulated during development, regeneration, and cancer. One key physical factor that regulates cell migration is topology. Most studies on surface topology and cell mechanics have been carried out with single migratory cells, yet little is known about the spreading and motility response of 3D complex multicellular tissues to topological cues. Here, we examine the behaviors of microsurgically isolated tissue explants composed of epithelial and mesenchymal cell layers from naturally 3D organized embryos of the aquatic frog Xenopus laevis to complex topological cues. We control topology using fabricated micropost arrays (MPAs) with different diameters (e.g., different spacing gaps) and investigate the collective 3D migration of these multicellular systems in these MPAs. Our topographical controlled approach for cellular application enables us to achieve a high degree of control over micropost positioning and geometry via simple, accurate, and repeatable microfabrication processes. We find that the topology regulates both collective and individual cell migration and that dense MPAs reduce but do not eliminate tissue spreading. By modulating cell size through the cell cycle inhibitor Mitomycin C or the spacing within MPAs we discover a role for topology in disrupting collective enhancement of cell migration. We find 3D topological cues can direct both single cell motility and tissue spreading, altering tissue-scale processes that enable efficient conversion of single cell motility into collective movement.
Lab on a Chip, 15(7):1667-1676, Royal Society of Chemistry, January 2015 (article)
Three-dimensional (3D) heterogeneous assembly of coded microgels in enclosed aquatic environments is demonstrated using a remotely actuated and controlled magnetic microgripper by a customized electromagnetic coil system. The microgripper uses different ‘stick–slip’ and ‘rolling’ locomotion in 2D and also levitation in 3D by magnetic gradient-based pulling force. This enables the microrobot to precisely manipulate each microgel by controlling its position and orientation in all x–y–z directions. Our microrobotic assembly method broke the barrier of limitation on the number of assembled microgel layers, because it enabled precise 3D levitation of the microgripper. We used the gripper to assemble microgels that had been coded with different colours and shapes onto prefabricated polymeric microposts. This eliminates the need for extra secondary cross-linking to fix the final construct. We demonstrated assembly of microgels on a single micropost up to ten layers. By increasing the number and changing the distribution of the posts, complex heterogeneous microsystems were possible to construct in 3D.
Precision Engineering, 39, pages: 125-133, Elsevier, January 2015 (article)
This paper introduces a new design approach to synthesize multiple degrees-of-freedom (DOF) flexure-based parallel mechanism (FPM). Termed as an integrated design approach, it is a systematic design methodology, which integrates both classical mechanism synthesis and modern topology optimization technique, to deliver an optimized multi-DOF FPM. This design approach is separated into two levels. At sub-chain level, a novel topology optimization technique, which uses the classical linkage mechanisms as DNA seeds, is used to synthesize the compliant joints or limbs. At configuration level, the optimal compliant joints are used to form the parallel limbs of the multi-DOF FPM and another stage of optimization was conducted to determine the optimal space distribution between these compliant joints so as to generate a multi-DOF FPM with optimized stiffness characteristic. In this paper, the design of a 3-DOF planar motion FPM was used to demonstrate the effectiveness and accuracy of this proposed design approach.
Lee, G., Kim, H., Seo, K., Kim, J., Sitti, M., Seo, T.
Journal of Field Robotics, November 2014 (article)
Climbing robots have been widely applied in many industries involving hard to access, dangerous, or hazardous environments to replace human workers. Climbing speed, payload capacity, the ability to overcome obstacles, and wall-to-wall transitioning are significant characteristics of climbing robots. Here, multilinked track wheel-type climbing robots are proposed to enhance these characteristics. The robots have been developed for five years in collaboration with three universities: Seoul National University, Carnegie Mellon University, and Yeungnam University. Four types of robots are presented for different applications with different surface attachment methods and mechanisms: MultiTank for indoor sites, Flexible caterpillar robot (FCR) and Combot for heavy industrial sites, and MultiTrack for high-rise buildings. The method of surface attachment is different for each robot and application, and the characteristics of the joints between links are designed as active or passive according to the requirement of a given robot. Conceptual design, practical design, and control issues of such climbing robot types are reported, and a proper choice of the attachment methods and joint type is essential for the successful multilink track wheel-type climbing robot for different surface materials, robot size, and computational costs.
In Intelligent Robots and Systems (IROS 2014), 2014 IEEE/RSJ International Conference on, pages: 4624-4629, September 2014 (inproceedings)
This paper proposes GeckoGripper, a novel soft, inflatable gripper based on the controllable adhesion mechanism of gecko-inspired micro-fiber adhesives, to pick-and-place complex and fragile non-planar or planar parts serially or in parallel. Unlike previous fibrillar structures that use peel angle to control the manipulation of parts, we developed an elastomer micro-fiber adhesive that is fabricated on a soft, flexible membrane, increasing the adaptability to non-planar three-dimensional (3D) geometries and controllability in adhesion. The adhesive switching ratio (the ratio between the maximum and minimum adhesive forces) of the developed gripper was measured to be around 204, which is superior to previous works based on peel angle-based release control methods. Adhesion control mechanism based on the stretch of the membrane and superior adaptability to non-planar 3D geometries enable the micro-fibers to pick-and-place various 3D parts as shown in demonstrations.
Hierarchical assembly of self-healing adhesive proteins creates strong and robust structural and interfacial materials, but understanding of the molecular design and structure–property relationships of structural proteins remains unclear. Elucidating this relationship would allow rational design of next generation genetically engineered self-healing structural proteins. Here we report a general self-healing and -assembly strategy based on a multiphase recombinant protein based material. Segmented structure of the protein shows soft glycine- and tyrosine-rich segments with self-healing capability and hard beta-sheet segments. The soft segments are strongly plasticized by water, lowering the self-healing temperature close to body temperature. The hard segments self-assemble into nanoconfined domains to reinforce the material. The healing strength scales sublinearly with contact time, which associates with diffusion and wetting of autohesion. The finding suggests that recombinant structural proteins from heterologous expression have potential as strong and repairable engineering materials.
As we move towards the miniaturization of devices to perform tasks at the nano and microscale, it has become increasingly important to develop new methods for actuation, sensing, and control. Over the past decade, bio-hybrid methods have been investigated as a promising new approach to overcome the challenges of scaling down robotic and other functional devices. These methods integrate biological cells with artificial components and therefore, can take advantage of the intrinsic actuation and sensing functionalities of biological cells. Here, the recent advancements in bio-hybrid actuation are reviewed, and the challenges associated with the design, fabrication, and control of bio-hybrid microsystems are discussed. As a case study, focus is put on the development of bacteria-driven microswimmers, which has been investigated as a targeted drug delivery carrier. Finally, a future outlook for the development of these systems is provided. The continued integration of biological and artificial components is envisioned to enable the performance of tasks at a smaller and smaller scale in the future, leading to the parallel and distributed operation of functional systems at the microscale.
We have developed a millimeter-scale magnetically driven swimming robot for untethered motion at mid to low Reynolds numbers. The robot is propelled by continuous undulatory deformation, which is enabled by the distributed magnetization profile of a flexible sheet. We demonstrate control of a prototype device and measure deformation and speed as a function of magnetic field strength and frequency. Experimental results are compared with simple magnetoelastic and fluid propulsion models. The presented mechanism provides an efficient remote actuation method at the millimeter scale that may be suitable for further scaling down in size for microrobotics applications in biotechnology and healthcare
Our goal is to understand the principles of Perception, Action and Learning in autonomous systems that successfully interact with complex environments and to use this understanding to design future systems