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Bioengineered and biohybrid bacteria-based systems for drug delivery

2016

Article

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The use of bacterial cells as agents of medical therapy has a long history. Research that was ignited over a century ago with the accidental infection of cancer patients has matured into a platform technology that offers the promise of opening up new potential frontiers in medical treatment. Bacterial cells exhibit unique characteristics that make them well-suited as smart drug delivery agents. Our ability to genetically manipulate the molecular machinery of these cells enables the customization of their therapeutic action as well as its precise tuning and spatio-temporal control, allowing for the design of unique, complex therapeutic functions, unmatched by current drug delivery systems. Early results have been promising, but there are still many important challenges that must be addressed. We present a review of promises and challenges of employing bioengineered bacteria in drug delivery systems and introduce the biohybrid design concept as a new additional paradigm in bacteria-based drug delivery.

Author(s): Hosseinidoust, Zeinab and Mostaghaci, Babak and Yasa, Oncay and Park, Byung-Wook and Singh, Ajay Vikram and Sitti, Metin
Journal: Advanced drug delivery reviews
Volume: 106
Pages: 27--44
Year: 2016
Month: November
Day: 15
Publisher: Elsevier

Department(s): Physical Intelligence
Research Project(s): Bacteria-propelled bio-hybrid microswimmers
Targeted cargo delivery using microbots
Bibtex Type: Article (article)

DOI: 10.1016/j.addr.2016.09.007

BibTex

@article{hosseinidoust2016bioengineered,
  title = {Bioengineered and biohybrid bacteria-based systems for drug delivery},
  author = {Hosseinidoust, Zeinab and Mostaghaci, Babak and Yasa, Oncay and Park, Byung-Wook and Singh, Ajay Vikram and Sitti, Metin},
  journal = {Advanced drug delivery reviews},
  volume = {106},
  pages = {27--44},
  publisher = {Elsevier},
  month = nov,
  year = {2016},
  month_numeric = {11}
}