A simple quantitative model of neuromodulation, Part I: Ion flow through neural ion channels
2024
Article
pi
We develop a simple model of ionic current through neuronal membranes as a function of membrane potential and extracellular ion concentration. The model combines a simplified Poisson–Nernst–Planck (PNP) model of ion transport through individual ion channels with channel activation functions calibrated from ad hoc in-house experimental data. The simplified PNP model is validated against bacterial gramicidin A ion channel data. The calibrated model accounts for the transport of calcium, sodium, potassium, and chloride and exhibits remarkable agreement with the experimentally measured current–voltage curves for the differentiated human neural cells.
| Author(s): | Werneck, Linda and Han, Mertcan and Yildiz, Erdost and Keip, Marc-André and Sitti, Metin and Ortiz, Michael |
| Journal: | Journal of the Mechanics and Physics of Solids |
| Volume: | 182 |
| Pages: | 105457 |
| Year: | 2024 |
| Department(s): | Physical Intelligence |
| Bibtex Type: | Article (article) |
| Paper Type: | Journal |
| DOI: | https://doi.org/10.1016/j.jmps.2023.105457 |
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BibTex @article{werneck2024simple,
title = {A simple quantitative model of neuromodulation, Part I: Ion flow through neural ion channels},
author = {Werneck, Linda and Han, Mertcan and Yildiz, Erdost and Keip, Marc-Andr{\'e} and Sitti, Metin and Ortiz, Michael},
journal = {Journal of the Mechanics and Physics of Solids},
volume = {182},
pages = {105457},
year = {2024},
doi = {https://doi.org/10.1016/j.jmps.2023.105457}
}
|
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