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Department Talks
  • Sangram Bagh
  • 2P04

The molecular connectivity between genes and proteins inside a cell shows a good degree of resemblance with complex electrical circuits. This inspires the possibility of engineering a cell similar to an engineering device by plugging in genetic logic circuits. This approach, which is loosely defined as synthetic biology is an emerging field of bioengineering, where scientist use electrical and computer engineering principle to re-program cellular functions with a potential to solve next generation challenges in medicine, materials, energy, and space travel. In this talk, we discuss our efforts to create artificial and complex chemical signal processing systems using genetic logic circuits and its applications in building a technology platform for microbial robotics. We further discuss our systems biology effort to understand the effect of microgravity on human and bacterial cells during space travel.

Organizers: Metin Sitti

  • Ingmar H. Riedel-Kruse
  • Max-Planck-Institute for Intelligent Systems, Heisenbergstraße 3, Stuttgart, Room 2P4

I will share my vision that microbiological systems should be as programmable, interactive, accessible, constructible, and useful as our personal electronic devices. Natural multi-cellular organisms and symbiotic systems achieve complex tasks through division of labor among cells. Such systems transcend current electronics and robotics in many ways, e.g., they synthesize chemicals, generate active physical forms, and self-replicate. Harnessing these features promises significant impact for manufacturing (bioelectronics / smart materials /swarm robotics), health (tissue engineering), chemistry (pathway modularization), ecology (bioremediation), biodesign (art), and more. My lab takes a synergistic bottom-up / top-down approach to achieve such transformative applications: (1) We utilize synthetic biology and biophysics approaches to engineer and understand multi-cell bacterial assemblies. We developed the first synthetic cell-cell adhesion toolbox [1] and optogenetic cell-surface adhesion toolbox (‘Biofilm Lithography’) [2]. Integration with standard synthetic biology components (e.g., for signaling, differentiation, logic) now enables a new intelligent materials paradigm that rests on versatile, modular, and composable smart particles (i.e., cells). (2) We pioneered ‘Interactive Biotechnology’ that enables humans to directly interact with living multi-cell assemblies in real-time. I will provide the rational for this interactivity, demonstrate multiple applications using phototactic Euglena cells (e.g., tangible museum exhibits [3], biology cloud experimentation labs [4], biotic video games [5]), and show how this technology aided the discovery of new microswimmer phototaxis control strategies [6]. Finally, I discuss architecture and swarm programming languages for future bio-electronic devices (i.e., ‘Biotic Processing Units’ – BPUs) [7,8]. REFs: [1] Glass, Cell ’18; [2] Jin, PNAS ’18; [3] Lee, CHI ACM ’15; [4] Hossain, Nature Biotech ‘16; [5] Cira, PLoS Biology ‘15; [6] Tsang, Nature Physics ’18; [7] Lam LOC ‘17; [8] Washington, PNAS ‘19.

  • Dr. František Mach
  • Stuttgart 2P4

The state-of-the-art robotic systems adopting magnetically actuated ferromagnetic bodies or even whole miniature robots have recently become a fast advancing technological field, especially at the nano and microscale. The mesoscale and above all multiscale magnetically guided robotic systems appear to be the advanced field of study, where it is difficult to reflect different forces, precision and also energy demands. The major goal of our talk is to discuss the challenges in the field of magnetically guided mesoscale and multiscale actuation, followed by the results of our research in the field of magnetic positioning systems and the magnetic soft-robotic grippers.

Organizers: Metin Sitti

  • Prof. Holger Stark
  • Stuttgart 2P4

Active motion of biological and artificial microswimmers is relevant in the real world, in microfluidics, and biological applications but also poses fundamental questions in non-equi- librium statistical physics. Mechanisms of single microswimmers either designed by nature or in the lab need to be understood and a detailed modeling of microorganisms helps to explore their complex cell design and their behavior. It also motivates biomimetic approaches. The emergent collective motion of microswimmers generates appealing dynamic patterns as a consequence of the non-equilibrium.

Organizers: Metin Sitti Zoey Davidson

  • Prof. Dr. Rahmi Oklu
  • 3P02

Minimally invasive approaches to vascular disease and cancer have revolutionized medicine. I will discuss novel approaches to vascular bleeding, aneurysm treatment and tumor ablation.

Organizers: Metin Sitti

  • Dr. Aude Bolopion and Dr. Mich
  • 2P4

This talk presents an overview of recent activities of FEMTO-ST institute in the field of micro-nanomanipulation fo both micro nano assembly and biomedical applications. Microrobotic systems are currently limited by the number of degree of freedom addressed and also are very limited by their throughput. Two ways can be considered to improve both the velocity and the degrees of freedom: non-contact manipulation and dexterous micromanipulation. Indeed in both ways movement including rotation and translation are done locally and are only limited by the micro-nano-objects inertia which is very low. It consequently enable to generate 6DOF and to induce high dynamics. The talk presents recent works which have shown that controlled trajectories in non contact manipulation enable to manipulate micro-objects in high speed. Dexterous manipulation on a 4 fingers microtweezers have been also experimented and show that in-hand micromanipulations are possible in micro-nanoscale based on original finger trajectory planning. These two approaches have been applied to perform micro-nano-assemby and biomedical operations

  • Dr. Greg Byrnes
  • Room 3P02 - Stuttgart

Gliding evolved at least nine times in mammals. Despite the abundance and diversity of gliding mammals, little is known about their convergent morphology and mechanisms of aerodynamic control. Many gliding animals are capable of impressive and agile aerial behaviors and their flight performance depends on the aerodynamic forces resulting from airflow interacting with a flexible, membranous wing (patagium). Although the mechanisms that gliders use to control dynamic flight are poorly understood, the shape of the gliding membrane (e.g., angle of attack, camber) is likely a primary factor governing the control of the interaction between aerodynamic forces and the animal’s body. Data from field studies of gliding behavior, lab experiments examining membrane shape changes during glides and morphological and materials testing data of gliding membranes will be presented that can aid our understanding of the mechanisms gliding mammals use to control their membranous wings and potentially provide insights into the design of man-made flexible wings.

Organizers: Metin Sitti Ardian Jusufi

  • Dr. Islam S. M. Khali
  • Stuttgart 2P4

Mechanical removal of blood clots is a promising approach towards the treatment of vascular diseases caused by the pathological clot formation in the circulatory system. These clots can form and travel to deep seated regions in the circulatory system, and result in significant problems as blood flow past the clot is obstructed. A microscopi-cally small helical microrobot offers great promise in the minimally-invasive removal of these clots. These helical microrobots are powered and controlled remotely using externally-applied magnetic fields for motion in two- and three-dimensional spaces. This talk will describe the removal of blood clots in vitro using a helical robot under ultrasound guidance. The talk will briefly introduce the interactions between the helical microrobot and the fibrin network of the blood clots during its removal. It will also introduce the challenges unique to medical imaging at micro-scale, followed by the concepts and theory of the closed-loop motion control using ultrasound feedback. It will then cover the latest experimental results for helical and flagellated microrobots and their biomedical and nanotechnology applications.

Organizers: Metin Sitti

  • Dr. Yiğit Mengüç
  • Room 3P02 - Stuttgart

Incredible biological capabilities have emerged through evolution. Of special note is the material intelligence that defines the bodies of living things, blurring the line between brain and body. Material robotics research takes the approach of imbuing power, control, sensing, and actuation into all aspects of a (primarily soft) robot body. In this talk, the research topics of material robotics currently underway in the mLab at Oregon State University will be presented. Soft active materials designed and researched in the mLab include liquid metal, biodegradable elastomers, and electroactive fluids. Bioinspired mechanisms include octopus-inspired soft muscles, gecko-inspired adhesives, and snake-like locomotors. Such capabilities, however, introduce new fundamental challenge in making materially-enabled robots. To address these limitation, the mLab is also innovating in techniques to rapidly and scalably manufacture soft materials. Though significant challenges remain to be solved, the development of such soft and materially-enabled components promises to bring robots more and more into our daily lives.

Organizers: Metin Sitti

Patient Inspired Engineering: Problem, device, solution

  • 26 February 2018 • 11:00 12:00
  • Professor Rahmi Oklu
  • Room 3P02 - Stuttgart

Minimally invasive approaches to the treatment of vascular diseases are constantly evolving. These diseases are among the most prevalent medical problems today including stroke, myocardial infarction, pulmonary emboli, hemorrhage and aneurysms. I will review current approaches to vascular embolization and thrombosis, the challenges they pose and the limitations of current devices and end with patient inspired engineering approaches to the treatment of these conditions.

Organizers: Metin Sitti