Medical Systems
Imaging, design, fabrication, instrumentation, control, and preclinical validation of small-scale medical robots have a wide range of scientific challenges that our CSF will serve in solving them. Such small-scale (milli/micrometer scale) wireless (untethered) robots would enable direct access to currently unreachable or dangerous-to-reach regions inside the human body for minimally invasive medical diagnostic or therapeutic operations. Such new wireless medical robotic systems would revolutionize the health care in the future, save more human lives, and improve our quality of life.
Mission
Imaging, design, fabrication, instrumentation, control, and preclinical validation of small-scale medical robots have a wide range of scientific challenges that our CSF will serve in solving them. Such small-scale (milli/micrometer scale) wireless (untethered) robots would enable direct access to currently unreachable or dangerous-to-reach regions inside the human body for minimally invasive medical diagnostic or therapeutic operations. Such new wireless medical robotic systems would revolutionize the health care in the future, save more human lives, and improve our quality of life.
The Medical Systems Central Scientific Facility (CSF) aims to provide scientific service related to preclinical medical imaging, medical instrumentation, ex vivo biological testing and validation, and related methods and technologies for small-scale medical robot systems.
Facilities
The Medical Systems CSF offices and labs are mainly located on the 4th floor of the main MPI-IS Stuttgart building and the Physics Hall in the MPI-IS Stuttgart building.
For any inquiries or request please contact this E-mail Medical Systems
Such facility includes:
- Preclinical medical imaging systems
- Magnetic resonance imaging (MRI) and positron emission tomography (PET) system for small animals (Bruker 7T BioSpec MRI/PET system)
- Mini C-arm for x-ray fluoroscopy
- Enclosed x-ray imaging system
- Ultrasound imaging system
- Biological test, imaging and characterization systems
- Mammalian cell culturing systems
- Bacteria cell culturing systems
- Confocal and fluorescence optical microscopy systems
- Fluorescence-activated cell sorting (FACS) system
- Histology analysis
- Small-scale medical robot systems
- Magnetically actuated milli- and microscale medical robots
- Acoustically actuated microscale medical robots
- Optically actuated microscale medical robots
- Biohybrid (cell-driven) microscale medical robots
- Pseudo-MRI actuation system
Expertise & Capabilities
The Medical Systems CSF has many expertise and capabilities relevant to small-scale medical robot systems, such as:
- Preclinical small-animal medical imaging using MRI, PET, x-ray fluoroscopy, ultrasound, photoacoustic, OCT, IVIS, etc. imaging
- Design and prototyping of small-scale synthetic or biohybrid medical robots
- Localization and tracking of small-scale medical robots using medical imaging modalities
- Small-scale medical robot actuation and control systems using custom-made magnetic systems, MRI gradient coils, acoustic systems, and optical systems integrated with medical imaging systems
- Converting the existing MRI systems into an intelligent medical robot system by adding feedback control, localization, wireless communication and power transfer, human-machine interface, and other functionalities
- In vitro biocompatibility and other functional testing and characterization of small-scale medical robots and their materials
- Scientific help in immunological and other body responses and physiological details of given medical applications, such as targeted drug delivery, minimally invasive surgery, hyperthermia, embolization, and unclogging vessels.
Members:
2024
Nanodiamond-Enhanced Magnetic Resonance Imaging
Jelena Lazovic, E. G. A. W. P. S. A. S. J. L. G. W. M. S.
Advanced Materials, 36(11):2310109, 2024 (article)
2022
Multifunctional 3D-Printed Pollen Grain-Inspired Hydrogel Microrobots for On-Demand Anchoring and Cargo Delivery
Lee, Y., Kim, J., Bozuyuk, U., Dogan, N. O., Khan, M. T. A., Shiva, A., Wild, A., Sitti, M.
Advanced Materials, 35(10):2209812, December 2022 (article)
Remotely Guided Immunobots Engaged in Anti-Tumorigenic Phenotypes for Targeted Cancer Immunotherapy
Dogan, N. O., Ceylan, H., Suadiye, E., Sheehan, D., Aydin, A., Yasa, I. C., Wild, A., Richter, G., Sitti, M.
Small, 18(46):2204016, October 2022 (article)
Hierarchical iron oxide nanocomposite: Bundle-like morphology, magnetic properties and potential biomedical application
Tadic, M., Lazovic, J., Kralj, S.
Ceramics International, 48(11):16015-16022, June 2022 (article)
Magnetic properties of mesoporous hematite/alumina nanocomposite and evaluation for biomedical applications
Tadic, M., Panjan, M., Tadic, B. V., Kralj, S., Lazovic, J.
Ceramics International, 48(7):10004-10014, 2022 (article)
Radio frequency sensing‐based in situ temperature measurements during magnetic resonance imaging interventional procedures
Bilgin, M. B., Tiryaki, M. E., Lazovic, J., Sitti, M.
Advanced Materials Technologies, 7(9):2101625, March 2022 (article)
High-Performance Magnetic FePt (L10) Surface Microrollers Towards Medical Imaging-Guided Endovascular Delivery Applications
Bozuyuk, U., Suadiye, E., Aghakhani, A., Dogan, N. O., Lazovic, J., Tiryaki, M. E., Schneider, M., Karacakol, A. C., Demir, S. O., Richter, G., Sitti, M.
Advanced Functional Materials, 32(8):2109741, 2022 (article)
2021
Fullerene-Filtered Light Spectrum and Fullerenes Modulate Emotional and Pain Processing in Mice
Lazovic, J., Zopf, L. M., Hren, J., Gajdoš, M., Slavkovic, M., Jovic, Z., Stankovic, I., Matovic, V., Koruga, D.
Symmetry, 13(11):2004, October 2021 (article)
Wireless MRI-powered reversible orientation-locking capsule robot
Erin, O., Boyvat, M., Lazovic, J., Tiryaki, M. E., Sitti, M.
Advanced Science, 8(13):2100463, 2021 (article)
Nonresonant powering of injectable nanoelectrodes enables wireless deep brain stimulation in freely moving mice
Kozielski, K. L., Jahanshahi, A., Gilbert, H. B., Yu, Y., Erin, O., Francisco, D., Alosaimi, F., Temel, Y., Sitti, M.
Science Advances, 7(3):eabc4189, 2021 (article)
2020
Elucidating the interaction dynamics between microswimmer body and immune system for medical microrobots
Injectable nanoelectrodes enable wireless deep brain stimulation of native tissue in freely moving mice
Kozielski, K. L., Jahanshahi, A., Gilbert, H. B., Yu, Y., Erin, O., Francisco, D., Alosaimi, F., Temel, Y., Sitti, M.
arXiv preprint arXiv:2001.11586, 2020 (article)
2019
Multifunctional magnetic hairbot for untethered osteogenesis, ultrasound contrast imaging and drug delivery
Singh, A. V., Ansari, M. H. D., Dayan, C. B., Giltinan, J., Wang, S., Yu, Y., Kishore, V., Laux, P., Luch, A., Sitti, M.
Biomaterials, 219, pages: 119394, Elsevier, 2019 (article)
Peptide-induced biomineralization of tin oxide (SnO2) nanoparticles for antibacterial applications
Singh, A. V., Jahnke, T., Xiao, Y., Wang, S., Yu, Y., David, H., Richter, G., Laux, P., Luch, A., Srivastava, A., Saxena, P. S., Bill, J., Sitti, M.
Journal of Nanoscience and Nanotechnology, 19(9):5674-5686, American Scientific Publishers, 2019 (article)